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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Acupuncture for heart failure: a Bayesian network systematic review and meta-analysis protocol.

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This meta-analysis evaluates acupuncture for heart failure (HF), assessing its efficacy and safety. It aims to clarify which acupuncture methods are most effective for improving heart function and patient outcomes.

Keywords:
Acupunctureheart failureprotocolsystematic review

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Area of Science:

  • Cardiovascular Medicine
  • Integrative and Complementary Medicine
  • Clinical Research Methodology

Background:

  • Heart failure (HF) represents the advanced stage of cardiovascular disease.
  • Clinical investigations into acupuncture for HF treatment are growing.
  • The effectiveness and safety of acupuncture interventions for HF remain uncertain.

Purpose of the Study:

  • To conduct a meta-analysis of randomized controlled trials (RCTs) on acupuncture for HF.
  • To provide high-quality evidence on the efficacy and safety of acupuncture in HF management.
  • To identify optimal acupuncture methods for treating heart failure.

Main Methods:

  • Comprehensive literature search across multiple databases (Cochrane Library, PubMed, Web of Science, SinoMed, CNKI, Wan-fang, VIP) up to June 2021.
  • Inclusion of RCTs on various acupuncture methods for HF, with independent data extraction and quality assessment.
  • Network meta-analysis (NMA) using RevMan 5.3 and ADDIS, incorporating risk of bias, meta-regression, subgroup, and sensitivity analyses.

Main Results:

  • Primary outcomes: efficacy rate and heart function improvement.
  • Secondary outcomes: quality of life, rehospitalization rates, and adverse events.
  • Evidence quality assessed using the GRADE framework.

Conclusions:

  • This study will determine the efficacy and safety of acupuncture for improving HF clinical symptoms and cardiac function.
  • It aims to identify the most suitable acupuncture techniques for heart failure patients.