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The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

Waleed Alhazzani1, Mohammed Alshahrani2, Fayez Alshamsi3

  • 1Department of Medicine, McMaster University, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Canada; GUIDE Center, St. Joseph's Healthcare Hamilton, Hamilton, Canada.

Journal of Infection and Public Health
|November 12, 2021
PubMed

Insights

Saudi experts developed evidence-based recommendations for managing severe COVID-19 in intensive care units (ICUs). The guidelines cover pharmacotherapeutic interventions, including immunomodulators and antivirals, to improve patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Rising COVID-19 cases necessitated expert guidance for intensive care unit (ICU) management.
  • The Saudi Critical Care Society (SCCS) convened a panel to address critical care challenges during COVID-19 waves.

Purpose of the Study:

  • To develop evidence-based recommendations for the therapeutic management of severe and critical COVID-19 in the ICU.
  • To provide a framework for adapting treatment strategies based on evolving evidence.

Main Methods:

  • A panel of 51 multidisciplinary experts was assembled.
  • The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach and evidence-to-decision (EtD) framework were utilized.
  • Systematic reviews and clinical trials were assessed to formulate recommendations.

Main Results:

  • Twelve recommendations were issued for pharmacotherapeutic interventions in severe/critical COVID-19.
  • Recommendations included immunomodulators, antiviral agents, and anticoagulants.
  • Three strong and nine weak recommendations were provided.

Conclusions:

  • The SCCS COVID-19 panel successfully formulated ICU management recommendations using the GRADE and EtD frameworks.
  • The guidelines are adaptable to different healthcare settings.
  • Recommendations will be updated as new evidence emerges.
Abstract

Keywords:
COVID-19Intensive care unitPractice guidelineTherapy

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