Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Building on models-a perspective for computational neuroscience.

Cerebral cortex (New York, N.Y. : 1991)·2025

Same author

Modeling neuron-astrocyte interactions in neural networks using distributed simulation.

PLoS computational biology·2025

Same author

Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.

Cerebral cortex (New York, N.Y. : 1991)·2024

Same author

Software in science is ubiquitous yet overlooked.

Nature computational science·2024

Same author

Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks.

PLoS computational biology·2023

Same author

Coherent noise enables probabilistic sequence replay in spiking neuronal networks.

PLoS computational biology·2023

Search research articles

Related Experiment Video

Updated: Oct 13, 2025

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo

Published on: May 4, 2018

NEST Desktop, an Educational Application for Neuroscience.

Sebastian Spreizer^1,2,3,4, Johanna Senk³, Stefan Rotter^5,2

¹Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany spreizer@uni-trier.de.

|November 12, 2021

Summary

This summary is machine-generated.

NEST Desktop offers an installation-free, web-based interface for simulating spiking neuronal networks. This tool lowers the barrier for students and educators in computational neuroscience, enhancing learning and research accessibility.

Keywords:

NEST simulator code generation graphical user interface neuronal dynamics teaching web-based application

More Related Videos

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Published on: July 1, 2015

Related Experiment Videos

Last Updated: Oct 13, 2025

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo

Published on: May 4, 2018

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Published on: July 1, 2015

Area of Science:

Computational Neuroscience
Neuroscience Software Development

Background:

Simulation software for spiking neuronal networks has advanced in performance and flexibility.
High entry barriers exist for students and early-career scientists due to programming and installation complexities.

Purpose of the Study:

To introduce NEST Desktop, an installation-free Graphical User Interface (GUI) for spiking neuronal network models.
To simplify the process of creating, simulating, and analyzing neuronal network models for educational purposes.

Main Methods:

Developed an open-source tool, NEST Desktop, with a web-browser-based GUI.
Decoupled the GUI from the simulation engine for flexible deployment (local or remote).
Integrated graphical elements for network creation, configuration, simulation execution, and results visualization.

Main Results:

NEST Desktop enables users to explore computational neuroscience concepts without prior programming knowledge.
The tool simplifies deployment and enhances robustness against software stack changes.
Facilitates both quality and intensity of teaching in computational neuroscience courses.

Conclusions:

NEST Desktop significantly lowers the entry barrier for computational neuroscience education and research.
The tool promotes equal opportunities in accessing neuroscience simulation resources.
Its web-based architecture ensures long-term accessibility and adaptability.