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Updated: Oct 13, 2025

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

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Published on: November 21, 2018

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Collagen Receptor Implicated in Immune Exclusion

    Cancer Discovery
    |November 12, 2021
    PubMed

    Insights

    An antibody drug targeting the discoidin domain receptor 1 (DDR1) helps overcome immune exclusion in triple-negative breast cancer. This approach allows T cells to infiltrate tumors, slowing cancer progression in preclinical models.

    Area of Science:

    • Immunology
    • Oncology
    • Pharmacology

    Background:

    • Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies.
    • Immune exclusion, where immune cells are blocked from tumors, is a major challenge in TNBC treatment.
    • Discoidin domain receptor 1 (DDR1) is implicated in tumor progression and immune evasion.

    Discussion:

    • An antibody targeting DDR1 was investigated for its potential to reverse immune exclusion in TNBC.
    • The antibody treatment demonstrated an ability to facilitate T cell infiltration into the tumor microenvironment.
    • This immune cell influx correlated with a reduction in tumor growth in a preclinical mouse model.

    Key Insights:

    • Targeting DDR1 with an antibody can overcome immune exclusion in triple-negative breast cancer.
    • Enhanced T cell infiltration into tumors leads to slowed tumor progression.
    • This strategy represents a novel therapeutic approach for aggressive breast cancer subtypes.

    Outlook:

    • Parthenon Therapeutics is advancing this DDR1-targeting antibody into clinical development.
    • Further clinical trials are necessary to validate the efficacy and safety in human patients.
    • This research opens new avenues for immunotherapy in difficult-to-treat cancers.

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