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Related Experiment Video

Updated: Oct 13, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Implication of thyroid function in periodontitis: a nationwide population-based study.

Eyun Song1, Min Jeong Park1, Jung A Kim1

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine and School of Medicine, Seoul, Korea.

Scientific Reports
|November 12, 2021
PubMed
Summary
This summary is machine-generated.

Low thyroid stimulating hormone (TSH) levels are linked to a higher risk of periodontitis, a common gum disease. This research highlights a potential connection between thyroid function and oral health, suggesting further investigation is warranted.

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Area of Science:

  • Endocrinology
  • Periodontology
  • Public Health

Background:

  • Periodontitis is linked to systemic diseases via inflammation and oxidative stress.
  • The association between periodontitis and thyroid dysfunction remains under-researched.
  • Thyroid dysfunction can impact overall health, including inflammatory processes.

Purpose of the Study:

  • To investigate the association between periodontitis and thyroid stimulating hormone (TSH) levels.
  • To determine if lower TSH levels correlate with an increased prevalence of periodontitis.
  • To explore the relationship in a large, population-based cohort.

Main Methods:

  • Utilized data from a nationwide population-level survey.
  • Included participants without pre-existing thyroid disease or medication.
  • Categorized participants into TSH tertiles and assessed periodontal status using the Community Periodontal Index.

Main Results:

  • A significant difference in periodontitis prevalence was observed across TSH tertiles.
  • The highest periodontitis prevalence was in the lowest TSH tertile (26.5%).
  • Low TSH levels were associated with significantly higher odds for periodontitis (OR 1.36).

Conclusions:

  • Low TSH levels are significantly associated with increased odds of periodontitis.
  • This finding suggests a potential link between thyroid function and periodontal health.
  • Further research is needed to elucidate the mechanisms underlying this association.