Related Experiment Video
Updated: Oct 22, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Effects of topical treatment with piroxicam on prostaglandin synthesis in experimental uveitis
Abstract:
We have assessed the efficacy of 0.5% piroxicam collyrium applied for 15 days to the eyes of rabbits in which uveitis had been experimentally induced. The results demonstrate the capability of the drug to easily overcome the ocular barrier. On the 30th day, a clear regression of the uveitis symptoms was observed, the hyperaemia having completely disappeared. By means of radioimmunological assay (RIA), it was found that the increased PGF2 alpha concentration in the aqueous humour had returned to normal levels.
More Related Videos
Related Concept Videos
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Acute Inflammation III: Local and Systemic Effects

