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Related Experiment Video

Updated: Oct 13, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Study of Cognitive Disfunctions in Thyroid Pathology.

Oana-Maria Nicola Marioara1, Mihaela Popescu2, Cristina-Nicoleta Vlădoianu3

  • 1Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Current Health Sciences Journal
|November 12, 2021
PubMed
Summary

Thyroid disease significantly impacts mental health, with depression and anxiety being common. Cognitive impairments like memory loss and poor concentration are also prevalent in individuals with thyroid conditions.

Keywords:
Hyperthyroidismanxietydepressionhypothyroidismmemory

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Psychiatry

Background:

  • Thyroid hormones critically influence brain function, affecting mood and cognition.
  • Thyroid pathology is linked to cognitive impairment, depression, and anxiety.

Purpose of the Study:

  • To investigate the association between thyroid disorders and cognitive dysfunction.
  • To explore the relationship between thyroid hormone levels (FT4, TSH) and depression/anxiety.

Main Methods:

  • Study included 130 patients from an Endocrinology Clinic (2014-2020).
  • Patients were treatment-naïve for thyroid medication and antidepressants.
  • Depression assessed using the Hamilton scale; anxiety using the Beck scale.

Main Results:

  • Depression diagnosed in 45.38% and anxiety in 46.92% of cases.
  • Cognitive impairment observed in 34.7% of hypothyroidism patients (memory/concentration issues).
  • Cognitive changes found in 51.42% of hyperthyroidism patients.

Conclusions:

  • Thyroid pathology frequently co-occurs with depression, anxiety, and cognitive deficits.
  • Long-standing thyroid illness is particularly associated with depression.
  • Thyroid dysfunction significantly impacts cognitive functions such as memory and concentration.