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Role of antibody-based therapy in indolent non-Hodgkin's lymphoma

Patrick Willard1, John McKay2, Victor Yazbeck1,3

  • 1Virginia Commonwealth University, Department of Internal Medicine, Richmond, VA, United States of America.

Leukemia Research Reports
|November 12, 2021
PubMed

Monoclonal antibodies (mAb) for indolent non-Hodgkin's lymphoma (iNHL) including follicular and marginal zone lymphomas was a key therapeutic development that changed the natural history of these diseases. Rituximab, a chimeric anti-CD20 mAb, was the first immunotherapy ever used in cancer, and a current cornerstone of lymphoma therapies. Since, we saw development of humanized antibodies, next generations anti-CD20, mAbs targeting other markers on tumor cells (CD19 and CD22), its microenvironment (PD-1, CD47), antibody drug conjugates and bispecific T cell engagers. Given their activity, safety and specificity, mAbs are well poised to remain an essential therapeutic tool for iNHL and other malignancies.

Keywords:
Antibody-drug conjugate, bispecific antibodies, treatmentImmunotherapiesIndolent non-Hodgkin lymphomaMonoclonal antibodiesbispecific antibodies, treatment

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