Related Experiment Video
Updated: Oct 13, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
A congenital syphilitic child to an adequately treated syphilitic mother
R Suganthy Rajakumari1, Sudha R Gopinath1, Nithya Mohan1
1Department of STD, Madurai Medical College, Government Rajaji Hospital, Madurai, Tamil Nadu, India.
A mentally ill antenatal mother of 34 weeks gestation was diagnosed as a case of latent syphilis of unknown duration and was treated adequately with benzathine penicillin. One month after last dose of penicillin she delivered a male baby without any clinical or radiological evidence of syphilis, but reactive RPR in 1:64 dilution. Baby was treated as per CDC guidelines. It is also the gestational age at which the mother was treated decides the outcome in child in addition to stage of syphilis. These reported congenital syphilis cases necessitates early screening and adequate treatment of syphilis mainly in pregnancy.
A mentally ill antenatal mother of 34 weeks gestation was diagnosed as a case of latent syphilis of unknown duration and was treated adequately with benzathine penicillin. One month after last dose of penicillin she delivered a male baby without any clinical or radiological evidence of syphilis, but reactive RPR in 1:64 dilution. Baby was treated as per CDC guidelines. It is also the gestational age at which the mother was treated decides the outcome in child in addition to stage of syphilis. These reported congenital syphilis cases necessitates early screening and adequate treatment of syphilis mainly in pregnancy.
Related Concept Videos
Sexually Transmitted Infections
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Teratogenicity
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

