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Possible physico-chemical processes in human dentin caries.

G Daculsi, R Z LeGeros, A Jean

    Journal of Dental Research
    |August 1, 1987
    PubMed
    Summary

    This study reveals beta-tricalcium phosphate (beta-TCP) forms in arrested dentin caries. Dissolution and reprecipitation of dentin mineral likely drives the formation of Mg-substituted beta-TCP crystals within dentin tubules.

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    Area of Science:

    • Biomaterials Science
    • Crystallography
    • Dental Research

    Background:

    • Dentin caries involves complex mineral changes.
    • Understanding the crystal-level events in arrested caries is crucial for developing remineralization strategies.
    • Beta-tricalcium phosphate (beta-TCP) has been observed in carious dentin, but its formation mechanism is not fully elucidated.

    Purpose of the Study:

    • To correlate ultrastructural observations of beta-tricalcium phosphate (beta-TCP) in arrested dentin caries with in vitro formation of Mg-substituted beta-TCP.
    • To investigate the physico-chemical processes at the crystal level during dentin caries progression and arrest.

    Main Methods:

    • High-resolution transmission electron microscopy (TEM) with microdiffraction and microanalysis for ultrastructural analysis of arrested dentin caries.
    • In vitro precipitation method to synthesize Mg-substituted beta-TCP from solutions with varying Mg/Ca molar ratios (starting from 5/95).

    Main Results:

    • Mg-substituted beta-TCP was successfully synthesized in vitro using a precipitation method.
    • Ultrastructural analysis revealed the presence of beta-TCP in arrested dentin caries.
    • Correlations suggest a chronological sequence of crystal events, involving dissolution of dentin mineral and reprecipitation of Mg-substituted beta-TCP and apatite.

    Conclusions:

    • The study postulates a mechanism for the formation of Mg-substituted beta-TCP and apatite in dentin tubules during caries arrest.
    • Initial dissolution of Mg- and CO3-rich dentin mineral (apatite) is followed by reprecipitation of Mg-substituted beta-TCP.
    • Subsequently, CO3- and Mg-poor apatite reprecipitates, suggesting a distinct chronological sequence of mineral transformation in carious dentin.

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