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Updated: Oct 13, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Highlighting DEM's Potential to Gauge Mechanistic Attributes of MUPS Tablet and Capsule Formulations
Shishir Shekhar1, Negin Amini1, David A V Morton1
13D Powders Group, School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Abstract:
Simulation of pharmaceutical unit operations by the discrete element method (DEM) has elevated our understanding of the impact of single-particle interactions on themselves, and on the entire tablets/powder. Studies in the past have shown how this knowledge helps to mitigate/solve multiple challenges during conventional formulation and process development/modernization/troubleshooting, with minimal use of active drug material. This communication adds to this- highlighting the tool's potential for a rapid preliminary assessment of the mechanistic attributes of multiple unit particle system (MUPS) based tablet and capsule drug products.
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