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Lipopeptide Pepducins as Therapeutic Agents

Emily Michael1, Lidija Covic1, Athan Kuliopulos2

  • 1Center of Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 12, 2021
PubMed
Summary

Pepducins, lipidated peptides targeting G protein-coupled receptors (GPCRs), offer versatile therapeutic potential. An advanced compound, PZ-128, demonstrated safety and efficacy in phase 2 cardiac trials for myonecrosis and thrombosis.

Keywords:
Atopic dermatitisCADFPRGPCRsNASHPAR1PAR2PZ-128Pepducinβ2AR

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