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Selective outcome reporting across psychopharmacotherapy randomized controlled trials
Michelle Lancee1, Marleen Schuring1, Joeri K Tijdink2
1Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht (UMCU), Utrecht University, Utrecht, The Netherlands.
International Journal of Methods in Psychiatric Research
|November 12, 2021
Summary
Selective reporting in psychopharmacotherapy trials is linked to non-industry funding and specific psychiatric disorders like major depressive disorder and schizophrenia. This highlights a need for greater transparency in clinical trial reporting.
Area of Science:
- Psychiatry and Behavioral Sciences
- Clinical Trial Methodology
- Evidence-Based Medicine
Background:
- Selective reporting of clinical trial outcomes can lead to biased interpretations of evidence.
- Ensuring accurate reporting is crucial for valid clinical decision-making in psychopharmacotherapy.
Purpose of the Study:
- To investigate factors associated with selective reporting in psychopharmacotherapy trials.
- To identify potential solutions for preventing selective reporting in future research.
Main Methods:
- A multivariate logistic regression analysis was conducted on registry records of trials for depressive, bipolar, and psychotic disorders.
- Explanatory variables included funding source, psychiatric disorder, study start date, participating centers, and sample size.
- Adjusted odds ratios (AOR) were calculated to assess the association with selective reporting.
Main Results:
- 14% of 151 included trials (N=94,303 participants) exhibited discrepancies between registered and published primary outcomes.
- Non-industry-funded randomized controlled trials (RCTs) had higher odds of selective reporting (AOR 5.3).
- Trials for major depressive disorder (AOR 12.7) and schizophrenia (AOR 14.5) showed significantly higher odds of selective reporting.
Conclusions:
- Discrepancies between trial registrations and publications are evident in trials for psychiatric disorders.
- Non-industry funded RCTs are particularly associated with selective reporting.
- Addressing selective reporting is essential for improving the reliability of clinical evidence in psychiatry.
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