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Published on: May 31, 2024
Congenital Pouch Colon: Further Histopathological Perspectives
Neha Singh1, Suravi Mohanty1, Inchara Yeliur Kalegowda1
1Department of Pathology, St. John's Medical College, Rajiv Gandhi University of Health Sciences, Bangalore, India.
Abstract:
Congenital pouch colon is an uncommon anomaly worldwide and is usually associated with anorectal malformations. Imperforate anus with a large air fluid level on the abdominal x ray suggests the diagnosis. Most cases are diagnosed in neonates and an early management limit complications. Few studies have documented the histopathological features of congenital pouch colon.
Abstract:
We present two cases with varied associated anomalies (Case 1 with rectovesical fistula, Case 2 with Mayer Rokitansky Kuster Hauser syndrome) and their histopathological features. Immunohistochemistry for calretinin showed paucity of ganglion cells and intrinsic fibers with occasional punctate positivity. The c-Kit immunostain documented fewer interstitial cells of Cajal. Cystitis glandularis with intestinal metaplasia (Case 1) and an additional muscle layer (Case 2) are described.
Abstract:
These novel histopathological features characterize the entity further and may be related to genesis of the pouch and its clinical manifestations.
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