Related Experiment Video
Updated: Oct 13, 2025
09:49
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
Published on: February 23, 2024
2.0K
Multifarious applications of bioactive glasses in soft tissue engineering
Shreyasi Majumdar1, Smriti Gupta1, Sairam Krishnamurthy1
1Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India. ksairam.phe@iitbhu.ac.in.
Biomaterials Science
|November 12, 2021
Summary
Bioactive glasses (BGs) show significant promise for soft tissue regeneration, promoting healing in wounds, gut, heart, lungs, and nerves. Further research is needed for clinical translation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Tissue engineering (TE) utilizes biomaterials to repair damaged tissues, overcoming limitations of grafts.
- Bioactive glasses (BGs) are recognized for bone regeneration but increasingly show potential in soft tissues.
- BGs offer flexibility, biocompatibility, and biodegradability, making them versatile TE scaffolds.
Purpose of the Study:
- To review the biological applications of bioactive glasses (BGs) in soft tissue regeneration.
- To explore the potential of BGs beyond skeletal applications in tissue engineering.
- To highlight the neovascularization and healing properties of BGs in various tissues.
Main Methods:
- Comprehensive literature review of preclinical studies on bioactive glasses for soft tissue repair.
- Analysis of studies focusing on BG applications in wound healing, gastroduodenal regeneration, cardiac, pulmonary, nerve, and musculoskeletal tissues.
- Evaluation of BG's role in promoting host tissue integration and neovascularization.
Main Results:
- Bioactive glasses promote neovascularization, essential for scaffold integration in TE.
- BGs demonstrate efficacy in healing acute and chronic wounds and restoring intestinal mucosa.
- Studies indicate BGs can aid regeneration in tissues with limited renewal capacity, such as the heart and lungs, and support peripheral nerve and musculoskeletal repair.
Conclusions:
- Bioactive glasses exhibit promising preclinical potential for diverse soft tissue regeneration applications.
- BGs facilitate host tissue integration and healing across various organ systems.
- Further rigorous pharmacological evaluations and standardized animal model studies are required for clinical translation.
