Related Experiment Video
Updated: Oct 13, 2025
05:07
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
11.1K
Chronic lymphocytic leukemia presenting as gingival swelling and tooth mobility
Ahmad A Hamdan1, Philippe Bouchard2, Ahmad I Hamdan3
1Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, School of Dentistry, The University of Jordan, Amman, Jordan.
Summary
Oral manifestations like gingival swelling and tooth mobility can indicate Chronic Lymphocytic Leukemia (CLL). This case highlights the importance of considering systemic diseases in dental diagnoses.
Area of Science:
- Hematology
- Oncology
- Oral Medicine
Background:
- Chronic Lymphocytic Leukemia (CLL) is a prevalent B-cell malignancy in developed nations.
- CLL involves the monoclonal proliferation of CD5+ B-cells, leading to lymphocyte accumulation.
- Oral manifestations of CLL are uncommon and infrequently documented.
Observation:
- A 67-year-old male presented with tooth mobility and gingival swelling.
- Physical examination revealed cutaneous pallor and bilateral cervical lymphadenopathy.
- Blood tests showed leukocytosis with marked lymphocytosis (88%) and mild thrombocytopenia.
Findings:
- Flow cytometry confirmed CLL, identifying monoclonal B-lymphocytes expressing characteristic markers (CD19, CD20, CD23, CD5, etc.).
- The patient's presentation included leukocytosis, lymphocytosis, and specific B-cell immunophenotypes.
- Diagnosis of CLL was established based on clinical, hematological, and immunophenotypic findings.
Implications:
- Oral healthcare professionals should consider CLL in the differential diagnosis of unexplained tooth mobility and gingival swelling.
- Associated symptoms like lymphadenopathy, fever, weight loss, and fatigue warrant systemic evaluation.
- Early recognition of oral signs can lead to timely diagnosis and management of CLL.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
149
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
149
01:25Endocarditis II: Clinical Features of Infective Endocarditis
46
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
46
01:27Disorders of Leukocytes
1.2K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.2K
01:16Primary Lymphoid Organs
10.2K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
10.2K