Related Experiment Video

Updated: Oct 13, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Fibroblast Growth Factor 23 Level and Cardiovascular Parameters in Children with Chronic Kidney Disease

Gaurav Singh1, Om P Mishra2, Abhishek Abhinay1

  • 1Division of Pediatric Nephrology, Department of Pediatrics, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Indian Journal of Pediatrics
|November 12, 2021
PubMed

Insights

Serum fibroblast growth factor 23 (FGF-23) levels increase with chronic kidney disease (CKD) severity. However, FGF-23 did not correlate with cardiovascular abnormalities in pediatric CKD patients, with systolic blood pressure being a key risk factor for increased carotid intima-medial thickness.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Biomarkers in Chronic Disease

Background:

  • Chronic kidney disease (CKD) in children is associated with cardiovascular complications.
  • Fibroblast growth factor 23 (FGF-23) is a biomarker implicated in CKD progression and cardiovascular disease.
  • Understanding the relationship between FGF-23 and cardiovascular parameters in pediatric CKD is crucial for risk stratification.

Purpose of the Study:

  • To investigate serum FGF-23 levels across different CKD grades in children.
  • To determine the prevalence of abnormal left ventricular mass index (LVMI), carotid intima-medial thickness (cIMT), and central pulse wave velocity (cPWV) in pediatric CKD.
  • To identify risk factors, including FGF-23, associated with these cardiovascular abnormalities.

Main Methods:

  • A cohort of 59 pediatric CKD patients (G2-G5) was studied.
  • Measurements included serum intact FGF-23, LVMI, cIMT, and cPWV.
  • Statistical analysis assessed correlations and risk factors for cardiovascular abnormalities.

Main Results:

  • Serum FGF-23 levels were significantly elevated in all CKD grades compared to controls and increased with CKD severity.
  • Abnormalities were prevalent: increased LVMI (71.2%), elevated cIMT (57.7%), and cPWV (26.9%).
  • FGF-23 correlated negatively with eGFRcr and positively with iPTH, phosphate, and alkaline phosphatase, but not with LVMI, cIMT, or cPWV. Only systolic BP SDS predicted increased cIMT.

Conclusions:

  • Serum FGF-23 levels rise with CKD progression in children but show no significant association with LVMI, cIMT, or cPWV.
  • Systolic blood pressure is a significant risk factor for increased cIMT in pediatric CKD.
  • Further research is needed to elucidate the role of FGF-23 in pediatric CKD cardiovascular complications.
Abstract

Keywords:
Carotid intima–media thicknessCentral pulse wave velocityChronic kidney diseaseFibroblast growth factor 23Left ventricular mass index

More Related Videos

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

4.9K
Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice08:32

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice

Published on: March 10, 2017

10.2K

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
27
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
149
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
107
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
120
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
193
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
149