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In Vitro Assay to Study Tumor-macrophage Interaction
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Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Jipeng Jiang1, Jie Mei2, Shaoqiong Yi3

  • 1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China; Postgraduate School, Medical School of Chinese PLA, Beijing 100853, PR China; Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China.

Advanced Drug Delivery Reviews
|November 12, 2021
PubMed

Insights

Tumor microenvironment (TME) modulation via vaccines targeting tumor-associated macrophages (TAMs) and microbes offers a novel therapeutic strategy. Nanotechnology enhances vaccine delivery for improved tumor targeting and TME regulation.

Area of Science:

  • Oncology
  • Immunology
  • Nanotechnology

Background:

  • The tumor microenvironment (TME) is crucial for tumor development, comprising immune cells, fibroblasts, and extracellular matrix.
  • Tumor-associated macrophages (TAMs) and microbes are key TME components that tumor cells manipulate to promote cancer progression.

Purpose of the Study:

  • To explore vaccine delivery strategies that remodel the TME by targeting TAMs and microbes.
  • To investigate how nanotechnology can enhance vaccine design for improved tumor immunotherapy.

Main Methods:

  • Review of TME characteristics and the roles of TAMs and microbes in tumor progression.
  • Analysis of nanotechnology applications in vaccine delivery systems for antigen and adjuvant administration.

Main Results:

  • Targeting TAMs and microbes within the TME can enhance vaccine specificity and immunogenicity.
  • Nanotechnology provides a suitable platform for developing novel tumor vaccines.

Conclusions:

  • Modulating the TME by targeting the interactions between tumor cells, TAMs, and microbes represents a promising therapeutic avenue.
  • Vaccine delivery systems utilizing nanotechnology offer a rapid approach for developing new cancer therapies.
Keywords:
MacrophageMicrobiotaTumor microenvironmentTumor vaccineVaccine delivery

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