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High sucrose diet does not impact spatial cognition in rats using advanced touchscreen technology.

Briannah Miles1, William Yang1, Gabi Dezsi1

  • 1Department of Neuroscience, Central Clinical School, Monash University, The Alfred Hospital, Melbourne, VIC 3004, Australia.

Behavioural Brain Research
|November 12, 2021
PubMed
Summary

High-sugar diets did not impair cognitive functions in rats. Advanced touchscreen tests showed no significant differences in spatial or non-spatial learning, suggesting some cognitive aspects are resilient to sucrose exposure.

Keywords:
Automated touchscreenCognitionHigh-sugar dietSpatial learningVisual discrimination

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Nutritional Science

Background:

  • Western diets high in sugar are linked to obesity, metabolic diseases, and potential cognitive deficits.
  • Previous studies indicated spatial learning impairment in rodents fed high-sugar diets.

Purpose of the Study:

  • To investigate the impact of chronic high sucrose intake on spatial and non-spatial cognitive functions in rats.
  • To assess cognitive performance using advanced touchscreen technology.

Main Methods:

  • Male Wistar rats were divided into two groups: one receiving daily 10% sucrose solution, the other receiving tap water.
  • After five weeks, rats were tested on Pairwise Discrimination, Location Discrimination, and Progressive Ratio tasks using automated touchscreens.

Main Results:

  • Rats on the sucrose diet showed significantly increased caloric intake but no significant differences in cognitive performance compared to controls.
  • No differences were observed in acquisition, reversal learning, motivation, or processing speed across all tested cognitive tasks.

Conclusions:

  • Chronic sucrose consumption in rats did not lead to measurable impairments in spatial or non-spatial learning tasks.
  • Findings suggest that certain cognitive functions may be resistant to high-sugar diets, and touchscreen technology may reveal nuances not captured by traditional methods.