Related Experiment Video
Updated: Oct 13, 2025
04:37
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
983
Worse Outcomes Are Associated With Proximal Femoral Replacement Following Periprosthetic Joint Infection
John Strony1, Kamolsak Sukhonthamarn2, Timothy L Tan1
1Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
The Journal of Arthroplasty
|November 12, 2021
Summary
Proximal femoral replacements (PFRs) show a 5-year survival of 67%, with periprosthetic joint infection leading to high failure rates. Dual-mobility implants may reduce dislocation risk in these complex cases.
Area of Science:
- Orthopedic Surgery
- Biomedical Engineering
- Reconstructive Surgery
Background:
- Proximal femoral replacements (PFRs) are utilized for severe bone loss.
- Indications are expanding beyond osteolysis to include infection and periprosthetic fractures.
- Evaluating PFR outcomes in non-neoplastic conditions is crucial.
Purpose of the Study:
- To investigate the clinical outcomes of proximal femoral replacements (PFRs) in non-neoplastic conditions.
- To assess survivorship and complication rates associated with PFRs.
- To identify risk factors for PFR failure.
Main Methods:
- Retrospective review of 46 patients undergoing PFR.
- Analysis of electronic medical records for indications, surgical details, and complications.
- Kaplan-Meier survival analysis and log-rank testing for survivorship evaluation.
Main Results:
- Overall 5-year implant survival was 67%.
- Patients with periprosthetic joint infection had a significantly higher failure rate (47%).
- A high dislocation rate of 17.4% was observed, though dual-mobility articulation showed benefit.
Conclusions:
- Proximal femoral replacement is a viable option for massive proximal femoral bone loss.
- Periprosthetic joint infection poses a substantial risk for PFR failure, primarily due to reinfection and instability.
- Dual-mobility articulation may reduce the risk of dislocation following PFR.
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
144
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
144
01:26Factors Affecting the Risk of Infection
12.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.8K
01:25Urinary Tract Infection II: Pathophysiology
125
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
125
01:16Bones of the Lower Limb: Femur and Patella
3.7K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
3.7K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.8K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.8K
01:23Peripheral Artery Disease V: Postoperative Nursing Management
53
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
53