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Echocardiographic Killip Classification

Assi Milwidsky1, Dahlia Greidinger2, Shir Frydman1

  • 1Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|November 12, 2021
PubMed

Insights

Echocardiographic Killip (eKillip) class, using diastolic grade and stroke volume index, improves mortality prediction in patients undergoing echocardiography. This novel hemodynamic assessment offers additive prognostic value beyond routine echocardiographic parameters.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Prognostics

Background:

  • Routine echocardiographic parameters like ejection fraction have limited predictive value for mortality.
  • Noninvasive hemodynamic data may offer additive prognostic value.
  • The study explores an echocardiographic correlate of the clinical Killip score.

Purpose of the Study:

  • To evaluate the prognostic value of an echocardiographic correlate of the Killip score (eKillip class).
  • To assess if eKillip class, based on diastolic grade and stroke volume index, improves risk stratification for mortality.
  • To determine if hemodynamic echocardiographic data has additive prognostic value.

Main Methods:

  • Retrospective study of 556 patients in sinus rhythm referred for echocardiography.
  • Development of the echocardiographic Killip (eKillip) classification using diastolic grade and stroke volume index.
  • Analysis of association between eKillip class and all-cause mortality using Cox regression.

Main Results:

  • eKillip class 1 was present in 68% of patients; classes 2-4 in 32%.
  • eKillip class was significantly associated with all-cause mortality (P < .001).
  • eKillip class remained independently associated with mortality in multivariate analysis (P = .04).

Conclusions:

  • The echocardiographic Killip (eKillip) class is associated with all-cause mortality in patients undergoing echocardiography.
  • This hemodynamic assessment provides valuable prognostic information.
  • eKillip class offers additive prognostic value beyond routine echocardiographic parameters.
Abstract

Keywords:
Diastolic gradeEchocardiographyKillip classificationMortalityStroke volume index

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