Related Experiment Video

Updated: Oct 13, 2025

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
12:49

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

14.1K

Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis

Zhenxi Li1, Jing Liu1, Hiroyuki Inuzuka1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|November 12, 2021
PubMed

Insights

Kisspeptins (KISS1) and their receptor (KISS1R) show complex roles in cancer metastasis. Their function is tissue-dependent, offering potential therapeutic targets for cancer treatment.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Cancer metastasis is a lethal hallmark of human cancers.
  • Kisspeptins, encoded by the KISS1 gene, were initially identified as metastasis suppressors.
  • Kisspeptins are ligands for G-protein-coupled receptor 54 (GPR54/KISS1R), crucial for the hypothalamic-pituitary-gonadal axis.

Purpose of the Study:

  • To review the epigenetic regulation of KISS1 gene expression.
  • To discuss the context-dependent and controversial roles of KISS1/KISS1R in cancer metastasis.
  • To explore KISS1/KISS1R signaling pathways and their therapeutic potential.

Main Methods:

  • Review of existing literature on KISS1/KISS1R in cancer.
  • Analysis of epigenetic mechanisms regulating KISS1 expression.
  • Examination of prometastatic and antimetastatic signaling pathways.

Main Results:

  • KISS1/KISS1R exhibits context-dependent roles in metastasis, acting as both a suppressor and promoter.
  • Epigenetic mechanisms significantly influence KISS1 gene expression.
  • The KISS1/KISS1R axis involves complex signaling pathways.

Conclusions:

  • The role of KISS1/KISS1R in cancer metastasis is intricate and tissue-specific.
  • Targeting the KISS1/KISS1R pathway presents a promising, albeit complex, therapeutic strategy for anticancer treatments.
Keywords:
Anticancer therapeuticsKISS1/KISS1RMetastasis

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