Advances in surface plasmon resonance-based biosensor technologies for cancer biomarker detection

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Biosensing Technology

Background:

• Surface plasmon resonance (SPR) is an optical technique enabling label-free detection of biomolecules.
• Early cancer diagnosis relies on identifying specific biomarkers for monitoring tumor progression and recurrence.
• SPR biosensors offer advantages like high sensitivity, accuracy, and low-cost fabrication for biomarker detection.

Purpose of the Study:

• To review recent advancements in SPR biosensing for diagnosing various cancer types.
• To evaluate the performance of SPR biosensors based on key quality assurance criteria.
• To discuss current limitations and future challenges in SPR-based cancer biomarker detection.

Main Methods:

• Literature review of recent progress in SPR biosensing technology.
• Evaluation of SPR biosensor performance metrics including limit of detection (LOD), selectivity, response time, and reusability.
• Analysis of SPR applications in diagnosing lung, breast, prostate, and ovarian cancers.

Main Results:

• SPR biosensing technology has shown significant progress in detecting cancer biomarkers.
• Performance evaluation indicates favorable sensitivity, accuracy, and label-free capabilities of SPR biosensors.
• Recent studies demonstrate the utility of SPR for early diagnosis across multiple cancer types.

Conclusions:

• SPR biosensors are a promising tool for early cancer diagnosis and monitoring due to their inherent advantages.
• Further research is needed to overcome limitations and enhance the clinical translation of SPR biosensors for cancer detection.
• Continued development in SPR technology will improve accuracy, speed, and reusability for comprehensive cancer management.