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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
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Local and network-level dysregulation of error processing is associated with binge drinking
Austin B Alderson Myers1, Donatello Arienzo1, Sean M Molnar1
1Department of Psychology, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182, USA.
Neuroimage. Clinical
|November 12, 2021
Summary
Young adult binge drinkers show altered brain activity and connectivity during inhibitory control tasks. These neural changes may compensate for deficits, offering insights into preventing excessive alcohol use.
Area of Science:
- Neuroscience
- Addiction Research
- Cognitive Psychology
Background:
- Binge drinking is prevalent in young adults and linked to neurofunctional changes and executive deficits.
- Error processing is crucial for behavioral modification and relapse prevention in addiction.
- Neural mechanisms underlying inhibition failures in binge drinking require further investigation.
Purpose of the Study:
- To examine local brain activity and functional connectivity during response inhibition errors in young adult binge drinkers (BDs) compared to light drinkers (LDs).
- To investigate the neural underpinnings of inhibition failures associated with binge drinking patterns.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was employed during a Go/NoGo task.
- Comparison of brain activity and interregional functional connectivity between BDs and LDs during inhibition errors.
Main Results:
- BDs and LDs showed similar performance on the Go/NoGo task.
- BDs exhibited greater fMRI activity in the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), and right middle frontal gyrus (R-MFG) during inhibition errors.
- BDs displayed increased connectivity between rACC and right lateral prefrontal cortex, and between R-MFG and left frontal regions.
Conclusions:
- Enhanced error-related activity and prefrontal connectivity in BDs may represent a compensatory mechanism to maintain inhibitory control.
- These findings highlight the role of top-down control in low-risk drinking and suggest potential early indicators of cognitive decline in BDs.
- The results may inform intervention strategies for preventing excessive alcohol consumption.
Keywords:
Binge drinkingCognitive controlError processingFunctional connectivityFunctional magnetic resonance imagingGo/NoGoMore Related Videos
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