Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026

Same author

Recognizing Coagulation Disorders in Sepsis in the Emergency Room: A Narrative Review.

Journal of clinical medicine·2026

Same author

Evaluation of Autoimmune FVIII Inhibitor Using Clot Waveform Analysis in Emicizumab-Treated Patients.

Journal of clinical medicine·2026

Same author

Diagnostic and Prognostic Evaluation of Disseminated Intravascular Coagulation Using the Disseminated Intravascular Coagulation Index.

Journal of clinical medicine·2025

Same author

Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation.

Thrombosis journal·2025

Same author

Evaluation of Deficiency and Excessive Condition of Thrombin Burst Using Laboratory Tests.

Thrombosis and haemostasis·2025

Search research articles

Related Experiment Video

Updated: Oct 13, 2025

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

The Reevaluation of Thrombin Time Using a Clot Waveform Analysis.

Hideo Wada¹, Yuhuko Ichikawa², Minoru Ezaki²

¹Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-0885, Japan.

Journal of Clinical Medicine

|November 13, 2021

Summary

Clot waveform analysis of thrombin time (CWA-TT) shows abnormalities in clotting factor deficiencies and is influenced by platelets. This suggests CWA-TT may be a valuable tool for diagnosing hemostatic abnormalities.

Keywords:

CWA platelet thrombin burst thrombin time

More Related Videos

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Published on: April 19, 2024

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Related Experiment Videos

Last Updated: Oct 13, 2025

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Published on: April 19, 2024

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Area of Science:

Hematology
Coagulation science
Diagnostic assays

Background:

Thrombin burst is a key coagulation mechanism, but clinical data from routine assays are limited.
Clot waveform analysis (CWA) offers a potential method to evaluate thrombin time (TT).

Purpose of the Study:

To evaluate the utility of CWA for assessing thrombin time (TT) as a diagnostic tool.
To investigate the impact of clotting factor deficiencies and platelet concentration on CWA-TT.

Main Methods:

Thrombin time (TT) was assessed using CWA with low thrombin concentrations.
Evaluations included plasma deficient in clotting factors, calibration plasma, platelet-poor plasma (PPP), and platelet-rich plasma (PRP).
Samples were obtained from healthy volunteers, thrombocytopenia patients, and malignant disease patients.

Main Results:

CWA-TT was abnormal in plasma with clotting factor deficiencies, particularly Factor VIII deficiency.
Platelet-rich plasma (PRP) showed distinct waveform patterns compared to platelet-poor plasma (PPP).
The second peak of the first derivative (1st DP-2) was altered in thrombocytopenia and malignant disease patient samples.

Conclusions:

CWA-TT demonstrates abnormalities in various clotting factor deficiencies.
Platelets significantly influence CWA-TT results.
CWA-TT shows promise as a diagnostic test for hemostatic abnormalities.