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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

149
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

82
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Related Experiment Video

Updated: Oct 13, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Decrease in CD14++CD16+ Monocytes in Low-Immunological-Risk Kidney Transplant Patients with Subclinical Borderline

Abelardo Caballero1, Teresa Vazquez-Sanchez2, Pedro Ruiz-Esteban2

  • 1Immunology Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, 29010 Malaga, Spain.

Journal of Clinical Medicine
|November 13, 2021
PubMed
Summary
This summary is machine-generated.

Low levels of CD14++CD16+ monocytes in peripheral blood may indicate subclinical kidney transplant inflammation. A significant decrease in these monocytes in graft blood suggests their recruitment to inflamed tissue, signaling borderline lesions.

Keywords:
CD14++CD16+borderline lesionskidney biopsykidney transplantmonocytes

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Area of Science:

  • Transplantation immunology
  • Renal cell biology
  • Flow cytometry analysis

Background:

  • Subclinical inflammation in kidney transplants can precede overt rejection.
  • Monocyte subsets, particularly CD14++CD16+, are implicated in immune responses.
  • Early detection of subclinical changes is crucial for graft survival.

Purpose of the Study:

  • To investigate the association between CD14++CD16+ monocyte levels and subclinical inflammatory infiltrates in kidney transplant recipients.
  • To determine if CD14++CD16+ monocyte distribution in peripheral blood and graft blood can predict borderline lesions (BL) below the rejection threshold.

Main Methods:

  • Analysis of CD14++CD16+ monocyte percentages in peripheral blood (PB) and fine-needle-aspiration biopsy (FNAB) blood using flow cytometry.
  • Study included 81 low-immunological-risk kidney transplant recipients with protocol biopsies at three months.
  • Comparison of monocyte levels between patients with normal biopsies, borderline lesions (BL), and those excluded for BK virus or rejection.

Main Results:

  • Patients with borderline lesions exhibited significantly lower CD14++CD16+ monocyte levels in PB compared to those with normal biopsies (p=0.047).
  • In patients with interstitial infiltrates, CD14++CD16+ monocyte levels were significantly higher in FNAB blood than in graft blood (p=0.006).
  • A 50% difference in CD14++CD16+ monocytes between graft blood and PB was a significant risk factor for BL (p=0.002), increasing risk sevenfold.

Conclusions:

  • Decreased CD14++CD16+ monocytes in peripheral blood may indicate their migration to graft tissue.
  • This monocyte redistribution is associated with subclinical inflammatory infiltrates and borderline lesions in kidney transplants.
  • Monitoring CD14++CD16+ monocyte levels offers a potential non-invasive marker for subclinical kidney transplant inflammation.