Improvements in the Effectiveness of Early Detection in Colorectal Cancer with Open-Label Randomised Study.

Area of Science:

• Gastroenterology
• Oncology
• Preventive Medicine

Background:

• Colorectal cancer (CRC) remains a significant health concern, necessitating effective screening strategies.
• Improving the quality of CRC screening is crucial for early detection and improved patient outcomes.
• Colonoscopy is a primary method for CRC screening, and its effectiveness can be enhanced.

Purpose of the Study:

• To assess the effectiveness of a collaborative intervention in colorectal cancer screening.
• To evaluate colonoscopy's ability to detect advanced adenomas as an indicator of screening quality.
• To compare adenoma detection rates between an intervention group and a control group.

Main Methods:

• An open-label, randomized controlled study design was employed for cancer screening.
• Two groups were established: an exposed to intervention group (EIG) and a control group (CG), with 1:1 matching.
• The study involved 167 participants in the EIG and 174 in the CG.

Main Results:

• The intervention group (EIG) visualized 449 polyps, with 274 adenomas (80.58%), including 100 advanced adenomas (36.49%).
• The control group (CG) visualized 321 polyps and 152 adenomas (82.60%).
• Key factors associated with adenoma detection included male sex (OR 2.52), withdrawal time ≥9 min (OR 34.67), and fractional dose (OR 7.81).

Conclusions:

• The collaborative intervention between primary care and hospital care demonstrated effectiveness in CRC prevention.
• The study achieved its objective of improving the effectiveness and quality of colorectal cancer screening (PCCR).
• Enhanced colonoscopy techniques, such as increased withdrawal time, significantly improve adenoma detection rates.