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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
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Factors Associated with Acute Community-Acquired Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing
Mónica Romero Nieto1,2, Sara Maestre Verdú1, Vicente Gil2,3
1Department of Internal Medicine, Elda General University Hospital, Elda/Sax, Road s/n, 03600 Elda, Alicante, Spain.
Journal of Clinical Medicine
|November 13, 2021
Summary
Male sex, smoking, hypertension, and recurrent UTIs are linked to ESBL-producing E. coli in pyelonephritis. This helps optimize antibiotic choices for better patient outcomes.
Area of Science:
- Infectious Diseases
- Urology
- Microbiology
Background:
- Community-acquired pyelonephritis (APN) is a common urinary tract infection.
- Extended-spectrum ß-lactamase (ESBL)-producing *Escherichia coli* (E. coli) pose a significant challenge for antibiotic therapy.
- Identifying risk factors for ESBL-producing *E. coli* in APN is crucial for optimizing empirical treatment.
Purpose of the Study:
- To identify factors associated with ESBL-producing *E. coli* in patients with acute community-acquired pyelonephritis.
- To inform and optimize empirical antibiotic selection for APN caused by *E. coli*.
Main Methods:
- Retrospective analysis of patients with community-acquired APN and confirmed *E. coli* infection.
- Data collection included demographics, comorbidities, and treatment history.
- Multivariate logistic regression models were used to identify independent predictors of ESBL presence, with ROC curve analysis for model performance.
Main Results:
- The study included 367 patients; 13% had ESBL-producing *E. coli* infections.
- Independently associated factors for ESBL included male sex (OR 2.296), smoking (OR 4.846), hypertension (OR 3.342), and recurrent urinary tract infections (OR 4.673).
- The developed model demonstrated good predictive performance with an Area Under the ROC Curve of 0.802.
Conclusions:
- Male sex, smoking, hypertension, and recurrent UTIs are significant risk factors for ESBL-producing *E. coli* in APN.
- These findings can aid clinicians in selecting appropriate empirical antibiotic therapy for APN.
- Improved risk stratification can lead to more effective treatment and better patient outcomes.
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