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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Current Concepts of Psoriasis Immunopathogenesis.

Marijana Vičić1, Marija Kaštelan1, Ines Brajac1

  • 1Department of Dermatovenereology, Medical Faculty University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary

Psoriasis is a chronic, immune-mediated disease affecting skin and joints. It involves genetic and environmental factors triggering immune cells and inflammatory pathways like IL-23/Th17.

Keywords:
IL-23/Th17 pathwayNK cellsNKT cellsT lymphocytesdendritic cellsetiologyimmunopathogenesiskeratinocytesmacrophagespsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Genetics

Background:

  • Psoriasis is a common, chronic, systemic inflammatory disease affecting skin and joints.
  • It impacts patients socially and emotionally, with significant comorbidities.
  • Affects 2-4% of the global population, second only to atopic dermatitis.

Purpose of the Study:

  • Provide a comprehensive overview of current knowledge on psoriasis.
  • Detail genetic and environmental etiological factors.
  • Explain the immunopathogenesis and key inflammatory pathways.

Main Methods:

  • Review of current scientific literature on psoriasis.
  • Analysis of genetic predisposition and environmental triggers.
  • Examination of immune cell interactions and cytokine pathways.

Main Results:

  • Psoriasis is multifactorial, involving genetic susceptibility and environmental triggers.
  • The IL-23/Th17 pathway is central to the immune response.
  • Innate and adaptive immune cells, including dendritic cells, T lymphocytes, and keratinocytes, interact to drive inflammation.

Conclusions:

  • Understanding psoriasis pathogenesis is crucial for effective treatment.
  • The interplay of genetic, environmental, and immune factors defines the disease.
  • Targeting key cellular and cytokine pathways offers therapeutic potential.