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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis.

Madina Sarsenova1,2, Assel Issabekova2, Saule Abisheva3,4

  • 1Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for treating rheumatoid arthritis (RA) by modulating the immune system. This review explores MSC-based therapies, their immunoregulatory mechanisms, and current research for enhanced RA treatment.

Keywords:
cell preconditioningcell therapyimmunomodulationinflammationmesenchymal stem cellsrheumatoid arthritis

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and destruction.
  • Conventional RA treatments have limitations, including side effects and drug resistance.
  • Mesenchymal stem cells (MSCs) possess immunomodulatory and differentiation potential.

Purpose of the Study:

  • To review conventional and MSC-based therapies for rheumatoid arthritis.
  • To elucidate the link between MSCs and the immune system in RA pathogenesis.
  • To discuss strategies for enhancing MSC efficacy in RA treatment.

Main Methods:

  • Review of current literature on MSCs and rheumatoid arthritis.
  • Analysis of MSC immunomodulatory properties and mechanisms.
  • Evaluation of preclinical and clinical studies on MSC-based RA therapy.

Main Results:

  • MSCs exhibit significant immunomodulatory effects relevant to RA.
  • MSC-based therapy presents a promising alternative to conventional RA treatments.
  • Strategies exist to enhance MSCs' therapeutic potential in RA.

Conclusions:

  • MSC-based therapy offers a novel approach for rheumatoid arthritis management.
  • Understanding MSC-immune system interactions is crucial for optimizing RA treatment.
  • Further research and clinical studies are needed to fully realize MSC potential in RA.