Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

4.1K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
4.1K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

159
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
159
Endocrine Signaling01:45

Endocrine Signaling

65.5K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
65.5K
Hormonal Regulation01:33

Hormonal Regulation

34.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
34.1K
Fluid Movement Between Compartments01:18

Fluid Movement Between Compartments

1.9K
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemerin, hypertension, and the imperative of sex-based analysis: lessons from Wabel et al.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Endothelial Dysfunction in Vascular Inflammation: The Role of NLRP3, NLRP10, AIM2, TLR9, and PANoptosis.

Handbook of experimental pharmacology·2026
Same author

Adipose Triglyceride Lipase and Gpr40 Contribute to the Anti-Contractile Effect of Perivascular Adipose Tissue.

Microcirculation (New York, N.Y. : 1994)·2026
Same author

Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective.

Medicina (Kaunas, Lithuania)·2026
Same author

Sex-specific vascular effects of menthol: TRPM8- and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries.

Canadian journal of physiology and pharmacology·2026
Same author

RhoA/Rho-Kinase Signaling in Vascular Smooth Muscle and Endothelium: Mechanistic Insights and Translational Implications in Hypertension.

Biomolecules·2025

Related Experiment Video

Updated: Oct 13, 2025

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.2K

Exosomes as Intercellular Messengers in Hypertension.

Olufunke Omolola Arishe1,2, Fernanda Priviero1,2, Stephanie A Wilczynski1,2

  • 1Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC 29209, USA.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary

Hypertension involves arterial wall changes and turbulent blood flow. This review explores how exosomes, as intercellular messengers, contribute to hypertension

Keywords:
exosomeshypertensionintercellular communication

More Related Videos

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
09:18

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique

Published on: November 9, 2018

9.7K
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
08:27

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

11.1K

Related Experiment Videos

Last Updated: Oct 13, 2025

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.2K
Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
09:18

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique

Published on: November 9, 2018

9.7K
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
08:27

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

11.1K

Area of Science:

  • Cardiovascular Science
  • Cell Biology
  • Molecular Medicine

Background:

  • Hypertension is a major risk factor for heart disease and mortality.
  • Pathophysiology involves arterial wall changes, turbulent blood flow, and endothelial dysfunction.
  • Hypertension arises from complex genetic and environmental interactions (Mosaic Theory).

Purpose of the Study:

  • To review the role of exosomes in hypertension.
  • To discuss exosomes as intercellular messengers in cardiovascular disease.

Main Methods:

  • Literature review of exosomes and hypertension.
  • Analysis of exosome biogenesis, composition, and function.
  • Synthesis of current understanding of exosome involvement in hypertension pathogenesis.

Main Results:

  • Exosomes are extracellular vesicles involved in intercellular communication.
  • They carry various molecules (nucleic acids, proteins, lipids) influencing cellular function.
  • Exosomes play a role in the pathophysiology of hypertension.

Conclusions:

  • Exosomes are key intercellular communicators in hypertension.
  • Understanding exosome function offers insights into disease mechanisms.
  • Exosomes represent potential therapeutic targets for hypertension.