Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

500
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
500
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.8K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.8K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

451
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
451
The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

20.8K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
20.8K
Minerals01:26

Minerals

527
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
527

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy.

International journal of biological sciences·2026
Same author

A Multifunctional Electrolyte Additive K<sub>3</sub>P<sub>7</sub> for Simultaneous Capacity Compensation and Interphase Regulation in Lithium-Ion Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

L-serine dose-dependently ameliorates high-selenium-induced insulin resistance in mice.

The Journal of nutritional biochemistry·2026
Same author

Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy.

Poultry science·2026
Same author

Deciphering electrochemomechanical interplay in rechargeable aqueous Zn||MnO<sub>2</sub> batteries.

Nature communications·2026
Same author

Host metabolism shapes the intestinal microbiota: a top-down paradigm of environmental selection pressure.

Gut microbes·2026

Related Experiment Video

Updated: Oct 13, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.4K

Trace Element Selenium Effectively Alleviates Intestinal Diseases.

Ruihua Ye1, Jiaqiang Huang2,3, Zixu Wang1

  • 1College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary
This summary is machine-generated.

Selenium (Se) is vital for gut health, acting through selenoproteins to combat inflammation. This review explores Se

Keywords:
IBDSeNPsintestinal diseasesseleniumselenoproteins

More Related Videos

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.6K
Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans
07:23

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Published on: December 3, 2019

15.1K

Related Experiment Videos

Last Updated: Oct 13, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.4K
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.6K
Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans
07:23

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Published on: December 3, 2019

15.1K

Area of Science:

  • Nutritional Science
  • Gastroenterology
  • Biochemistry

Background:

  • Selenium (Se) is an essential trace element crucial for numerous biological functions, primarily through its incorporation into selenoproteins.
  • Chronic inflammatory intestinal diseases pose significant health risks with limited treatment options.
  • Selenium's potent antioxidant properties show promise in mitigating intestinal inflammation.

Purpose of the Study:

  • To elucidate the role and mechanisms of selenium and selenoproteins in the intestinal tract.
  • To evaluate the efficacy of nano-selenium (nano-Se) compared to traditional selenium supplements for intestinal diseases.
  • To provide insights into selenium's interaction with intestinal health for future research.

Main Methods:

  • Literature review focusing on the biological functions of selenium and selenoproteins in the gut.
  • Analysis of studies investigating selenium's effects on inflammatory bowel diseases (IBDs) and other intestinal disorders.
  • Comparative assessment of nano-selenium and conventional selenium preparations in preclinical and clinical contexts.

Main Results:

  • Selenium, via selenoproteins, plays a key role in antioxidant defense and immune modulation within the intestine.
  • Evidence suggests selenium supplementation can alleviate symptoms and inflammation in various intestinal diseases.
  • Nano-selenium presents unique properties that may enhance its bioavailability and therapeutic potential compared to traditional forms.

Conclusions:

  • Selenium and its derivatives, particularly nano-selenium, hold significant therapeutic potential for managing chronic inflammatory intestinal diseases.
  • Further research is warranted to optimize selenium-based interventions for intestinal health.
  • Understanding the precise mechanisms of selenium in the gut is crucial for developing effective prevention and treatment strategies.