Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice.

Communications biology·2026
Same author

Brain Monoamine Deficits in the CD Mouse Model of Williams-Beuren Syndrome.

Biomolecules·2025
Same author

Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders.

Dialogues in clinical neuroscience·2025
Same author

Widespread and Heterologous Effects of L-DOPA on Monoaminergic Tissue Metabolism in Newborn Rats Expressing Air-Stepping.

International journal of molecular sciences·2025
Same author

Physical exercise restores adult neurogenesis deficits induced by simulated microgravity.

NPJ microgravity·2024

Related Experiment Video

Updated: Oct 13, 2025

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.5K

Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain.

Alexandra Gros1,2, Léandre Lavenu1,2, Jean-Luc Morel1

  • 1CNRS, IMN, UMR 5293, University Bordeaux, F-33000 Bordeaux, France.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary

Simulated microgravity alters brain monoamine levels, particularly noradrenaline and dopamine in motor systems. This spaceflight condition also reorganizes serotonin and dopamine interactions, impacting brain function.

Keywords:
correlative analysisdopaminehindlimb unloading suspensionmetaboliteneurochemistrynoradrenalineserotoninsystem biologyvestibular system

More Related Videos

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.2K
Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
07:54

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

14.4K

Related Experiment Videos

Last Updated: Oct 13, 2025

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.5K
Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.2K
Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
07:54

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

14.4K

Area of Science:

  • Neuroscience
  • Space Biology
  • Neurochemistry

Background:

  • Spaceflight-induced microgravity affects astronaut behavior.
  • Monoaminergic systems (noradrenaline, dopamine, serotonin) are crucial for adaptive behaviors.
  • The impact of microgravity on these systems is not well understood.

Purpose of the Study:

  • To investigate the effects of simulated microgravity (SMG) on monoamine distribution in rat brains.
  • To identify specific brain regions and neurotransmitter systems affected by SMG.

Main Methods:

  • Utilized a simulated microgravity model in male Long Evans rats.
  • Analyzed monoamine (noradrenaline, dopamine, serotonin) levels in 30 brain regions.
  • Examined correlations between monoamine metabolism indices.

Main Results:

  • SMG altered noradrenaline and/or dopamine levels in vestibular/motor system regions.
  • Dopamine and serotonin levels decreased in the prelimbic cortex.
  • Increased correlations in serotonin and dopamine metabolism were observed across brain regions.

Conclusions:

  • Simulated microgravity induces early, localized changes in noradrenaline and dopamine within motor systems.
  • These changes are linked to significant reorganization of monoaminergic systems, especially involving serotonin.
  • Findings highlight potential neurochemical adaptations to spaceflight relevant to behavior.