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Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

Anmol Sharma1, Heena Khan1, Thakur Gurjeet Singh1

  • 1Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India.

International Journal of Molecular Sciences
|November 13, 2021
PubMed

Insights

The ubiquitin-proteasome pathway regulates cell functions; its dysregulation drives cancer. Targeting ubiquitin-proteasome enzymes offers promising therapeutic strategies for various cancers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The ubiquitin-proteasome pathway (UPP) is crucial for protein degradation and cellular homeostasis.
  • Aberrant UPP function, involving ubiquitinating enzymes (E1, E2, E3) and the proteasome, is linked to cancer development.
  • Understanding UPP's role in oncogenic signaling is vital for cancer therapy.

Purpose of the Study:

  • To review enzymes in the ubiquitin-proteasome pathway that promote oncogenesis.
  • To discuss downstream signaling pathways affected by UPP in cancer.
  • To highlight therapeutic strategies targeting UPP components for cancer treatment.

Main Methods:

  • Systematic literature review of major scientific databases (PubMed, Medline, Scopus, EMBASE).
  • Analysis of in vitro and in vivo studies on UPP involvement in diverse cancers.
  • Examination of downstream signaling pathways and therapeutic interventions.

Main Results:

  • Identified key ubiquitin-proteasome enzymes acting as pro-oncogenic factors.
  • Detailed the involvement of UPP in various cancer types and their signaling pathways.
  • Summarized the efficacy of UPP inhibitors in preclinical and clinical settings.

Conclusions:

  • The ubiquitin-proteasome pathway is a significant driver of cancer.
  • Targeting specific UPP enzymes and proteasome components shows therapeutic potential.
  • Further research and clinical trials are warranted for UPP-targeted cancer therapies.
Keywords:
cancerdeubiquitinationubiquitin inhibitorsubiquitin-proteasome systemubiquitination

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