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DSLINK: a computer program for gene-centromere linkage analysis in families with a trisomic offspring
American Journal of Human Genetics
|September 1, 1987
Summary
Trisomic individuals aid gene-centromere mapping by allowing analysis of two chromatids per meiosis. A new computer program, DSLINK, enables linkage analysis using both trisomic and disomic offspring data.
Area of Science:
- Genetics
- Molecular Biology
- Bioinformatics
Background:
- Trisomic individuals offer unique insights into gene-centromere mapping due to recoverable chromatids during meiosis.
- Existing linkage analysis programs are limited as they primarily consider disomic individuals.
Purpose of the Study:
- To develop a computational tool for gene-centromere linkage analysis incorporating data from trisomic individuals.
- To facilitate the study of recombination and chromosome segregation in the context of gene mapping.
Main Methods:
- Development of a FORTRAN computer program named DSLINK.
- Utilizing data from nuclear families with trisomic and disomic offspring for linkage analysis.
Main Results:
- DSLINK enables gene-centromere linkage analysis using information from both trisomic and disomic individuals.
- The program allows for the investigation of the relationship between recombination and chromosome segregation.
Conclusions:
- The DSLINK program expands the capabilities of gene-centromere mapping by including trisomic data.
- This approach enhances the understanding of meiotic processes and genetic linkage.