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Proteomics as a Complementary Technique to Characterize Bladder Cancer.
Rubén López-Cortés1, Sergio Vázquez-Estévez2, Javier Álvarez Fernández2
1Research Unit, Hospital Universitario Lucus Augusti (HULA), Servizo Galego de Saúde (SERGAS), 27002 Lugo, Spain.
Cancers
|November 13, 2021
Summary
Bladder cancer (BC) research is advancing with molecular classifications and proteomics. This review highlights proteomics
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Bladder cancer (BC) is a common urinary tract tumor with conventional and molecular classifications.
- Next-generation sequencing and immunohistochemistry aid in BC staging and understanding tumorigenic pathways.
- Current protein marker adoption in clinical practice is limited.
Purpose of the Study:
- To review bladder cancer classifications, emphasizing proteomics contributions.
- To present advances in mass spectrometry for histoproteomics.
- To discuss proteins relevant to BC pathophysiology and therapy development.
Main Methods:
- Review of bladder cancer epidemiology and classifications.
- Exploration of next-generation sequencing and immunohistochemistry advancements.
- Focus on mass spectrometry techniques for histoproteomics.
Main Results:
- Molecular classifications offer insights into BC tumorigenic pathways for precision medicine.
- Proteomics, particularly histoproteomics, is emerging as a key tool.
- Selected proteins are discussed for understanding BC pathophysiology.
Conclusions:
- Proteomics holds significant potential for developing novel bladder cancer therapies.
- Further research is needed to translate proteomic findings into clinical applications.
- Histoproteomics represents a promising frontier in bladder cancer research.
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