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Type I Interferon Promotes Antitumor T Cell Response in CRPC by Regulating MDSC

Lilv Fan1, Guiliang Xu1, Jingjing Cao1

  • 1Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

Cancers
|November 13, 2021
PubMed
Summary

Granulocytic myeloid-derived suppressor cells (G-MDSCs) drive castration-resistant prostate cancer (CRPC) progression. Interferon-alpha (IFNα) effectively reduces G-MDSCs and enhances anti-tumor immunity, offering a promising CRPC immunotherapy.

Keywords:
G-MDSCIFNαimmunotherapyprostate cancer

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