[Changes in the cytologic and electrophysiologic parameters of rat oocytes in response to prostaglandins F2 alpha and...

Influence of prostaglandins F-2 alpha and E-2 on ovulation character and on the state of the ovulated gametes has been studied in rats at the preovulatory period (the preparations have been injected for 3 days, beginning from the 1st day of early proestrus). Under the effect of prostaglandins the amount of postovulated ova decreases, especially in the animals given prostaglandin E-2. Inhibition of ovulation in these animals is accompanied with an increased part of hyperpolarized ova, appearance of some signs of degeneration in the group of depolarized oocytes and absence of oocytes with polarized membrane at the metaphase I stage. These facts can be interpreted as desynchronization of maturation processes and ova ovulation. Mechanisms of the changes revealed in the ovulatory process and the state of gametes under the prostaglandins effect are discussed.