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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Nephrotic Syndrome I : Introduction01:24

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Updated: Oct 13, 2025

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Multisystem inflammatory syndrome in children

Selda Hançerli Törün1, Dilek Yilmaz Çiftdoğan, Ateş Kara

  • 1Department of Pediatrics, Pediatric Infectious Disease Unit, İstanbul University Faculty of Medicine, İstanbul, Turkey

Turkish Journal of Medical Sciences
|November 13, 2021
PubMed
Summary
This summary is machine-generated.

Multisystem inflammatory syndrome in children (MIS-C) is a severe COVID-19 complication in pediatric patients. Prompt diagnosis and treatment are crucial for managing this critical condition.

Keywords:
COVID-19childrenMultisystem inflammatory syndrome

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Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Critical care medicine

Background:

  • Children can contract COVID-19, with initial reports from China indicating milder symptoms compared to adults.
  • A severe inflammatory condition, multisystem inflammatory syndrome in children (MIS-C), emerged in Europe in 2020, affecting children with SARS-CoV-2 infection.

Purpose of the Study:

  • To review the pathophysiology, clinical presentation, laboratory findings, diagnostic approaches, and treatment strategies for MIS-C.
  • To highlight the critical need for rapid diagnosis and management of MIS-C.

Main Methods:

  • Literature review focusing on MIS-C.
  • Synthesis of information on pathogenesis, clinical manifestations, diagnostics, and therapeutics.

Main Results:

  • MIS-C presents with multi-organ involvement due to uncontrolled immune system inflammation.
  • Symptoms include fever, abdominal pain, shock, and myocardial insufficiency, often requiring intensive care.

Conclusions:

  • MIS-C is a serious post-COVID-19 complication in children with potentially fatal outcomes.
  • Timely diagnosis and management are essential for improving patient outcomes in MIS-C.