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Altered static and dynamic functional network connectivity in post-traumatic headache.

Fengfang Li¹, Liyan Lu¹, Song'an Shang¹

¹Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, 210006, Nanjing, China.

The Journal of Headache and Pain

|November 14, 2021

Summary

Post-traumatic headache (PTH) after mild traumatic brain injury (mTBI) is linked to altered brain network connectivity. These functional connectivity changes may serve as biomarkers for identifying and managing mTBI-related headaches.

Keywords:

Functional magnetic resonance imaging Functional network connectivity Mild traumatic brain injury Post-traumatic headache

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Area of Science:

Neuroscience
Medical Imaging
Neurology

Background:

Post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (mTBI).
The underlying pathophysiological mechanisms of PTH remain poorly understood.
Aberrant functional network connectivity (FNC) is implicated in various pain disorders.

Purpose of the Study:

To investigate alterations in static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) in mTBI patients with PTH.
To explore the relationship between FNC alterations and clinical variables in mTBI patients.

Main Methods:

Recruited 50 mTBI patients with PTH and 39 mTBI patients without PTH.
Utilized resting-state functional magnetic resonance imaging (fMRI) and analyzed sFNC and dFNC using independent component analysis and the sliding window method.
Examined nine resting-state networks and correlated FNC differences with headache frequency, intensity, and Montreal Cognitive Assessment (MoCA) scores.

Main Results:

mTBI patients with PTH exhibited altered sFNC, including decreased SN-SMN and VN-DMN connectivity and increased SN-ECN and SMN-DMN connectivity.
Significant group differences in dFNC were observed, with increased connectivity alterations in specific states (State 2) and reduced changes in others (State 4).
The number of state transitions positively correlated with headache frequency, and dwell time in State 1 negatively correlated with MoCA scores.

Conclusions:

mTBI patients with PTH demonstrate distinct patterns of altered sFNC and dFNC.
These FNC alterations offer insights into the neuropathological mechanisms of PTH.
Altered FNC may serve as a potential imaging biomarker for identifying and predicting mTBI with PTH.