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Updated: Oct 13, 2025

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Chylothorax and Pseudochylothorax
Cassandra M Braun1, Jay H Ryu1
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Gonda 18 South, 200 First Street, Southwest, Rochester, MN 55905, USA.
Abstract:
Classically, both chylothorax and pseudochylothorax present as a pleural effusion with a characteristic milky white appearance to the pleural fluid. Although both are rare causes of pleural effusion, they have distinct etiologies and clinical implications, and as a result require different management strategies. Pleural fluid analysis of cholesterol and triglyceride levels is key to differentiating the 2 entities from one another and then guide the clinician to determine the best next steps in evaluation and management.
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