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Tertiary and Postrenal Transplantation Hyperparathyroidism.

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Endocrinology and Metabolism Clinics of North America
|November 14, 2021
PubMed
Summary

Kidney transplant recipients often have mineral metabolism issues, particularly high parathyroid hormone (PTH) levels. This review covers the impact and management of post-transplant hyperparathyroidism.

Keywords:
Bone diseaseCalciumHyperparathirodismKidney transplantation

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Area of Science:

  • Nephrology
  • Endocrinology
  • Transplantation Medicine

Background:

  • Kidney transplant recipients (KTxps) often retain metabolic abnormalities from end-stage renal disease.
  • Mineral metabolism (MM) parameters, including calcium, phosphorus, vitamin D, and parathyroid hormone (PTH), are frequently disturbed post-KTx.
  • There is a lack of consensus on managing PTH disorders in KTxps.

Purpose of the Study:

  • To review the prevalence, epidemiologic, and clinical impact of post-KTx hyperparathyroidism (hyper-PTH).
  • To outline diagnostic investigations and therapeutic strategies for managing PTH disorders in KTxps.

Main Methods:

  • Literature review focusing on mineral metabolism and PTH disorders in kidney transplant recipients.
  • Synthesis of data on prevalence, clinical significance, diagnostic approaches, and treatment options.

Main Results:

  • Post-KTx hyper-PTH is a common complication with significant clinical implications.
  • Altered calcium, phosphorus, vitamin D, and PTH levels are characteristic.
  • Current management strategies and diagnostic tools are discussed.

Conclusions:

  • Effective monitoring and management of mineral metabolism, especially PTH levels, are crucial for KTxps.
  • Further research and consensus are needed for optimal care of post-transplant hyper-PTH.
  • Addressing these metabolic anomalies can improve patient outcomes.