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Associations between galectin-1, left ventricular diastolic dysfunction, and heart failure with preserved ejection

Yi-Lin Tsai1, Ruey-Hsing Chou2, Ya-Wen Lu1

  • 1Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Journal of Cardiology
|November 14, 2021
PubMed

Insights

Elevated serum galectin-1 levels are linked to left ventricular diastolic dysfunction (DD) and increased risk of heart failure with preserved ejection fraction (HFpEF) and mortality in patients with angina.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation Research

Background:

  • Galectin-1, a glycan-binding protein, exhibits anti-inflammatory effects.
  • Left ventricular diastolic dysfunction (DD) is a critical factor in heart failure and mortality.
  • The complex pathophysiology of DD necessitates further investigation into associated biomarkers.

Purpose of the Study:

  • To investigate the association between serum galectin-1 levels and DD.
  • To explore the relationship between serum galectin-1 levels, DD, and incident heart failure with preserved ejection fraction (HFpEF).
  • To assess the prognostic value of galectin-1 in patients with angina pectoris.

Main Methods:

  • Prospective enrollment of 258 patients with angina pectoris symptoms.
  • Assessment of serum galectin-1 levels and echocardiographic parameters.
  • Evaluation of a composite endpoint including all-cause mortality or new-onset HFpEF.

Main Results:

  • Patients with higher galectin-1 levels showed increased left ventricular mass, left atrial diameter, and DD prevalence.
  • Elevated galectin-1 levels were significantly associated with the composite endpoint (p=0.039).
  • High galectin-1 remained a significant predictor of DD (OR 2.44, p=0.005) and was linked to poorer survival (log rank p=0.043) after adjustment.

Conclusions:

  • Elevated serum galectin-1 levels are associated with left ventricular diastolic dysfunction.
  • Higher galectin-1 levels predict an increased risk of all-cause mortality and incident HFpEF.
  • Galectin-1 may serve as a potential biomarker for adverse cardiovascular outcomes in patients with angina.
Abstract

Keywords:
Diastolic dysfunctionGalectin-1Heart failure

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