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COVID-19 Diagnosis: Current and Future Techniques.

Aarjoo Sharma1, Sanjeev Balda1, Mansi Apreja1

  • 1Department of Microbiology, Panjab University, Chandigarh, India.

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|November 14, 2021
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Summary
This summary is machine-generated.

The COVID-19 pandemic requires reliable diagnostic methods. This review covers current and emerging SARS-CoV-2 detection techniques, including RT-PCR, serology, and novel point-of-care tests, to combat the global health threat.

Keywords:
BiosensorsCOVID-19CRISPR-CasDiagnosisNanobodiesNucleic acidsSerology

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Area of Science:

  • Infectious Diseases
  • Diagnostic Technologies
  • Public Health

Background:

  • The COVID-19 pandemic poses a significant global threat, necessitating accurate and rapid diagnostic tools.
  • Current SARS-CoV-2 detection methods like RT-PCR, serological assays, and radiology have limitations.
  • There is an ongoing need for accessible, cost-effective, sensitive, and specific point-of-care diagnostic solutions.

Purpose of the Study:

  • To review existing and emerging diagnostic tests for SARS-CoV-2 infection.
  • To highlight advancements in diagnostic strategies for both clinical and research applications.
  • To provide an overview of methods aimed at improving COVID-19 diagnosis and control.

Main Methods:

  • Review of current diagnostic techniques including RT-PCR, serological assays, and radiology.
  • Exploration of emerging technologies such as RT-LAMP, NASBA, CRISPR-Cas-based detection, and digital PCR.
  • Analysis of diagnostic test development for clinical and research settings.

Main Results:

  • RT-PCR remains the primary method for SARS-CoV-2 detection.
  • Serological assays are valuable for community antibody prevalence studies.
  • Emerging technologies show promise for point-of-care diagnostics but require further approval.

Conclusions:

  • A diverse range of diagnostic methods are available and under development for SARS-CoV-2.
  • Continued innovation is crucial for developing improved, accessible COVID-19 diagnostic tools.
  • Effective diagnostics are essential for managing the ongoing COVID-19 pandemic and preventing its spread.