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The global hearing therapeutic pipeline: 2021
Beverley Isherwood1, Ana Cláudia Gonçalves2, Rick Cousins3
1Medicines Discovery Catapult, Alderley Edge, UK.
Drug Discovery Today
|November 14, 2021
Summary
New therapeutics are emerging to treat hearing loss, a condition impacting over 1.5 billion people. While promising, these treatments face challenges in development and translation to clinical use.
Area of Science:
- Otolaryngology
- Neuroscience
- Pharmacology
Background:
- Hearing loss affects over 1.5 billion people globally.
- Current hearing aids do not restore natural hearing and have limitations in noisy environments.
- There is a significant unmet need for effective hearing loss therapeutics.
Purpose of the Study:
- To analyze the current therapeutic pipeline for inner ear and central auditory processing disorders.
- To identify innovative assets and assess their translational potential.
- To highlight challenges and opportunities within the hearing loss therapeutic landscape.
Main Methods:
- Systematic analysis of the therapeutic pipeline for hearing loss.
- Inclusion of assets in clinical trials and preclinical development.
- Assessment of pipeline growth and recent entry trends.
Main Results:
- Identified 23 assets in clinical trials and 56 in preclinical development for hearing loss.
- 25% of identified assets entered the pipeline in the last three years, indicating rapid growth.
- The pipeline shows innovative potential but faces translational hurdles.
Conclusions:
- The growing therapeutic pipeline offers hope for treating hearing loss.
- Overcoming translational challenges is crucial for advancing new hearing loss treatments.
- Strategic support and strengthening of the pipeline are needed to address global hearing loss needs.
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