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Published on: March 31, 2021
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy
Yaseen Hussain1, Haroon Khan2, Imad Ahmad2
1College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Background:
With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies.
Purpose:
We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemical targeting the CRISPR/Cas9 system.
Results:
Genome engineering has been significantly accelerated by the advancement of the CRISPR/Cas9 technique. Phytochemicals play a key role in treating cancer by targeting various mechanisms and pathways.
Conclusions:
The use of CRISPR/Cas9 for nanoscale delivery of phytochemicals opens new avenues in cancer therapy. One of the main obstacles in the clinical application of CRISPR/Cas9 is safe and efficient delivery. As viral delivery methods have certain drawbacks, there is an urgent need to develop non-viral delivery systems for therapeutic applications.
Insights
CRISPR/Cas9 technology combined with nanoscale delivery of phytochemicals offers new cancer treatment strategies. Developing safe, non-viral delivery systems is crucial for clinical applications of this genome engineering tool.
Area of Science:
- Oncology
- Genetics
- Nanotechnology
Background:
- Cancer remains a leading cause of death globally, driving research into targeted therapies.
- While targeted agents improve survival, drug resistance limits therapeutic options.
- CRISPR/Cas9 technology accelerates the identification of new cancer targets and cell-based treatments.
Purpose of the Study:
- To explore CRISPR/Cas9 applications in cancer therapy.
- To discuss the nanoscale delivery of phytochemicals utilizing the CRISPR/Cas9 system.
Main Methods:
- Leveraging CRISPR/Cas9 for genome engineering in cancer research.
- Investigating phytochemicals for their anti-cancer mechanisms.
- Exploring nanoscale delivery systems for therapeutic agents.
Main Results:
- CRISPR/Cas9 advancements significantly enhance genome engineering capabilities.
- Phytochemicals demonstrate efficacy in targeting diverse cancer pathways.
- Nanoscale delivery systems show promise for enhanced therapeutic delivery.
Conclusions:
- CRISPR/Cas9 combined with nanoscale phytochemical delivery presents novel cancer therapy avenues.
- Efficient and safe delivery of CRISPR/Cas9 is a key challenge for clinical translation.
- Non-viral delivery systems are needed to overcome limitations of current viral methods.
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