Related Experiment Video
Updated: Oct 13, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Managing the gastrointestinal side effects of GLP-1 receptor agonists in obesity: recommendations for clinical
Sean Wharton1, Melanie Davies2,3, Dror Dicker4
1York University, McMaster University and Wharton Weight Management Clinic, Toronto, ON, Canada.
Abstract:
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are well established in clinical practice for the treatment of type 2 diabetes, and are approved and recommended for weight management in overweight or obesity. Gastrointestinal side effects are well known as the most common adverse effects of these agents and represent a potential barrier for use, particularly at higher doses. Drawing on both published evidence and our collective clinical experience, we aim to guide practitioners through managing these side effects with a view to optimizing therapeutic outcomes with GLP-1RAs.
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Glinides
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

