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Updated: Oct 13, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
How cancer cells remodel lipid metabolism: strategies targeting transcription factors
Do-Won Jeong1,2, Seulbee Lee1,2, Yang-Sook Chun3,4,5
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Abstract:
Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy.
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