A mapping platform for mitotic crossover by single-cell multi-omics
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Updated: Oct 13, 2025

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Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
Published on: July 11, 2025
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1Department of Human Genetics, University of California, Los Angeles, CA, Unites States.
Methods in Enzymology
|November 15, 2021
Abstract:
Mitotic crossovers have the potential to cause large-scale genome rearrangements. Here, we describe high-throughput, single-cell, whole-genome sequencing methods for mapping crossovers genome-wide at scale. The methods are generalizable to various eukaryotes and to other end points requiring high-throughput, high-coverage single cell sequencing.

