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Updated: Oct 13, 2025

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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CB2 and toll-like receptors crosstalk in microglia
Antonio Carlos Pinheiro de Oliveira1, Fabricio A Moreira1, Bernd L Fiebich1
1Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Trends in Neurosciences
|November 15, 2021
Abstract:
Microglia play a major role in certain neuropathological conditions. In a recent paper, Reusch et al. demonstrated how signaling pathways downstream of cannabinoid type 2 (CB2) and toll-like receptors (TLRs) converge in these cells. The findings suggest that CB2 receptors play a permissive role in microglia activation mediated by TLRs.

